Green Chemistry Case Studies
Codexis, Inc. & Dr. Yi Tang, UCLA – 2012 PGCCA Winner in the Area of Greener Synthetic Pathways
Title: An Efficient Biocatalytic Process to Manufacture Simvastatin
Summary: Simvastatin, a leading drug for treating high cholesterol, is manufactured from a natural product. The traditional multistep synthesis was wasteful and used large amounts of hazardous reagents. Professor Tang conceived a synthesis using an engineered enzyme and a practical low-cost feedstock. Codexis optimized both the enzyme and the chemical process. The resulting process greatly reduces hazard and waste, is cost-effective and meets the needs of customers. Some manufacturers in Europe and India use this process to make simvastatin.