Tools for Green Chemistry & Engineering

The innovative green chemistry tools on this page have been developed by the ACS GCI Pharmaceutical Roundtable and made available to the greater community. These tools are the unique output of the Roundtable’s collaboration among member companies and represent hundreds of hours of work. They are catalysts to spark new conversations in the lab and inspire further integration within companies. 


Solvent Selection Guide

Industry views solvent selection as a key component in the overall sustainability profile of a manufacturing process. In the pharmaceutical industry, around 50% of materials used to manufacture bulk active pharmaceutical ingredients are solvents. In addition, solvents contribute to about 80% of the process mass intensity (see presentation below for reference). For these reasons, the Pharmaceutical Roundtable developed a solvent selection guide based on health, safety, and environmental criteria. 


Process Mass Intensity Calculator

Decreasing the overall quantity of materials used to create a product is a significant challenge for companies that green chemistry can address. In addition to environmental benefits, decreasing materials used saves companies money. It is of particular importance in the pharmaceutical industry because manufacturing molecularly complex drugs requires more steps and more material than in the fine or bulk chemical manufacturing sectors. The Process Mass Intensity (PMI) metric was developed as a way to benchmark and quantify improvements towards a greener manufacturing process. The PMI Calculator enables you to quickly determine the PMI value by accounting for the raw material inputs and bulk API outputs of a process.


Convergent Process Mass Intensity Calculator

In order to enhance the PMI calculator to accommodate convergent synthesis, the ACS GCI Pharmaceutical Roundtable has released this 2.0 version. The Convergent PMI Calculator uses the same calculations, but allows multiple branches for single step or convergent synthesis. Instructions are included.