Molecule of the Week

Exiguamine A and B

September 29, 2008

Exiguamine A (R = H) and B (R = OH), natural products derived from a marine sponge found in the waters of Papua New Guinea, are potent inhibitors of a promising enzyme target implicated in several types of cancer. The total synthesis of both compounds was reported in Nature Chemical Biology in August. They inhibit the enzyme indoleamine-2,3-dioxygenase, which is overexpressed in many tumor cell lines, correlates with a poor prognosis for some cancers and seems to play a role in the “immune escape” mechanisms that solid tumors use to avoid recognition by the immune system.

Get more information on this molecule from CAS (Chemical Abstracts Service)