Molecule of the Week

Phenylboronic acid

January 5, 2009

Phenylboronic acid, or benzeneboronic acid, is prepared by the reaction of the Grignard reagent PhMgBr with B(OMe)3. It and its aryl-substituted derivatives are commonly used as building blocks in synthetic organic chemistry—most often in the Suzuki coupling reaction, in which a boronic acid reacts with an organic halide to form a carbon–carbon bond. Boronic acids’ reactions with 1,2- and 1,3-diols are useful for saccharide recognition.

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