Drug Design and Delivery Symposium

(DDS #1) Watch this overview of the drug discovery and development process to learn the stages and challenges in every step.

(DDS #2) Listen in on a discussion on the big four druggable families and the difference between small molecule and biotherapeutic targets.

(DDS #3) Discover how drug-likeness is a deceiving concept, explore the Rule of Five, and show how lessons from the past may guide the present.

(DDS #4) Learn strategies on how to effectively optimize small molecule hits and rapidly assess your findings.

(DDS #5) What do you need to know when filing for Investigational New Drug submissions to the United States Food and Drug Administration?

(DDS #6) Learn how the properties of the candidate impact decisions in the discovery process.

(DDS #7) Review the basic principles of Pharmaco-economics in drug development strategies as well as its role in determining health insurance coverage of drug products.

(DDS #8) Explore how how risks and challenges will be dealt with in the future and the key skill sets required of future medicinal chemists.

(January) Learn various factors that can be used to improve candidate quality from Dr. Paul Leeson.

(February) Learn a number of different strategies for improving drug solubility through structural modification.

(March) Finding the right drug target is becoming increasingly difficult. Learn how focusing on the smaller picture can have big results.

(April) Learn the pros and cons of different screening strategies.

(May) Jonathan Baell shares some tips on how to avoid the dead ends of drug discovery.

(June) Join Lei Zhang as he lays out a set of preferred parameters for which has yielded successful PET ligands and reduced resources and timelines.

(July) Jon Mason and Miles Congreve describe what protein-ligand X-ray data can do for you.

(August) Discover the pros and cons of the different solid state forms and what to consider when selecting.

(September) Gain an understanding of acceptable drug delivery approaches to support preclinical dose escalation.

Learn about key pharmacokinetic concepts including clearance, volume of distribution, half life and protein binding.

(November) John Higgins shares the utility of prodrugs, their general properties and prerequisites for optimal performance.

(January) Robert Copeland starts things off with a look at the importance of target conformational dynamics.

(February) Jules Remenar introduces the basics of LAIs and introduces techniques for using them properly.

(March) Mengwei Hu provides an overview of MR formulation strategies for insoluble compounds.

(April) Our special panel highlight the attributes and capabilities needed by the future medicinal chemist.

(May) Scott Lokey will cover the property space within which drug-like passive membrane permeability can be achieved in traditionally non-druglike scaffolds.

(June) L. Nathan Tumey will provide an overview of how medicinal chemistry strategies can be applied to optimize the efficacy and stability of ADCs.

(July) Punit Seth describes the use of chemical modification strategies to enhance oligonucleotide drugs.

(August) Vincent Stoll of Abbvie and Robert Wenslow of Crystal Pharmatech cover some of the basics of Protein X-ray Crystallography in this special broadcast.

(September) Deepak Dalvie of Pfizer discusses pragmatic risk mitigation strategies for toxicity and the path forward for drug candidates that carry a RM liability.

(October) Matt Disney describe efforts to obtain such compounds to help decipher the varied roles of RNA in disease biology.

(November) Dehua Pei shares how cyclic CPPs may finally realize the potential originally hoped for cell-penetrating peptides

(January) Timothy Heffron will discuss the unmet need for neurooncology treatments and considerations for brain-penentrant kinase inhibitor programs.

(February) Stuart Conway will introduce current understanding of the molecular basis of epigenetic processes, and explain how these findings are being exploited in medicinal chemistry to develop medicines with innovative new mechanisms of action.

(March) Stefan Gross shows how targeting these unique adaptations could lead to drugs with potential to transform clinical outcomes across many cancer types.

(April) Peter Grootenhuis delivers a brief overview of the drug discovery approaches and challenges to identify small molecules CFTR modulators.

(May) Jason Sello describes how applications of conformational analysis, structure-based design, and fragment-based design optimize the medicinal properties of natural products which yield molecules with great potential as drug candidates.

(June) Carl Nathan will review the biology that frames the problem, the innovation gap that exacerbates it and the new work that qualifies TB drug discovery as an innovation engine.