Anti-Infectives: Rational Approaches to the Design and Optimization
Though many natural products are used in clinical and veterinary medicine, those lacking the potency or pharmacological properties for deployment in medicine can be optimized using rational approaches that are informed by structure and mechanism. Join Jason Sello of Brown University as he describes how applications of conformational analysis, structure-based design, and fragment-based design optimize the medicinal properties of natural products which yield molecules with great potential as drug candidates.
What You Will Learn
- How principles of conformational analysis can be used to optimize receptor-binding and cell-permeability of small molecules
- How selectivity in the covalent inhibition of enzymes can be achieved through consideration of their catalytic mechanisms and substrate-specificities
- How structures of bioactive natural products can inform fragment-based drug discovery and optimization
The Fine Print
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