Human Exosomes: An Ideal Vehicle for Delivery of Therapeutic RNAs to Cells and Organs

Thursday, November 29, 2018 at 2pm ET 
Session 10 of the 2018 Drug Design and Delivery Symposium

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RNA has great potential as a therapeutic molecule for treating various diseases. It can either be used to silence pathological genes using RNA interference (RNAi) or express therapeutic proteins by delivering mRNA to cells. However, this process is not without its complications. An effective carrier is required to transport the RNAs to the cells and organs and the process needs to be safe, efficient and non-immunogenic.

Join Associate Professor Hadi Valadi of the Sahlgrenska Academy and Institute of Medicine at the University of Gothenburg in Sweden in this free interactive broadcast as he discusses what is known about exosomes, which are the nano-sized vesicles that allow cells to send RNA-messages to each other. After this broadcast, you will understand how human exosomes naturally transport a cargo of RNAs and proteins between the body's cells, as well if it is possible to utilize them to deliver therapeutic RNAs to cells and organs in order to treat or cure diseases.

What You Will Learn

  • A overview of exosomes: secretion, their mother cells, and their presence in different body fluids
  • How exosomes transport different RNA like mRNA and miRNA between cells
  • What are the prospects for using human exosomes as biological drug-delivery-vehicles to transport functional RNAs to cells and organs

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The Fine Print

ACS Webinars® does not endorse any products or services. The views expressed in this presentation are those of the presenters and do not necessarily reflect the views or policies of the American Chemical Society.

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Hadi Valadi
University of Gothenburg

Alexander Kapustin

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