Strategies to Improve Solubility of Drug Candidates

February 26, 2015
Session 2 of the Drug Design and Delivery Symposium

Blue Pills labeled 2

In the second session of our symposium, Dr. Michael Walker presents the factors that govern the aqueous solubility of small molecule drugs. In addition, a number of different strategies for improving solubility through structural modification are presented. Join us to learn what can stand in the way of optimizing solubility and ask your questions. 

*Access to this recording is an exclusive benefit for ACS Members. 

What You Will Learn

  • The obstacles faced by medicinal chemists when attempting to optimize solubility in the face of other physiochemical parameters
  • General strategies for improving solubility through structural modification and a suggested priority for executing the different approaches
  • Recent examples from the literature which highlight underappreciated structural changes which lead to improved solubility

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The Fine Print

ACS Webinars® does not endorse any products or services. The views expressed in this presentation are those of the presenters and do not necessarily reflect the views or policies of the American Chemical Society.


Michael Walker 
Bristol-Myers Squibb 

Nick Meanwell
Bristol-Myers Squibb 

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