Drug-Target Kinetics in Drug Design

January 28, 2016
Session 1 of the 2016 Drug Design and Delivery Symposium

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We're kicking things off with a bang in 2016! Join us as Robert Copeland starts things off with a look at the importance of target conformational dynamics and its impact on drug affinity.  The drug-target residence time model will be introduced and its applications in drug design will be reviewed.

What You Will Learn

  • The kinetic and equilibrium differences between closed and open systems and how these affect drug-target interactions in vitro and in vivo.
  • The impact of drug-dissociation rates and drug-target residence time on in vivo pharmacology.
  • Examples of the application of the drug-target residence time model to lead optimization.

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The Fine Print

ACS Webinars® does not endorse any products or services. The views expressed in this presentation are those of the presenters and do not necessarily reflect the views or policies of the American Chemical Society.

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Dan Erlanson
Carmot Therapeutics

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