Advanced Nano-Delivery Systems: Facilitating Tumor Delivery and Mitigating Resistance
The development of drug resistance is one of the most important clinical consequences of chemotherapy in the treatment of cancer. Rationale strategies are required to mitigate MDR in the clinical setting using a multipronged approach. Join Mansoor Amiji of Northeastern University in this free interactive broadcast as he discusses his research over the last 15 years on nanotechnology solutions for enhancing delivery efficiency in solid tumors and overcoming multidrug resistance (MDR). By employing innovative methods like using modulation of apoptotic threshold with exogenous ceramide, inhibition of glycolytic metabolism and lactate production, and RNA interference therapy to silence genes responsible for resistance development, his group has shown that tumor drug resistance can be effectively mitigated with a multipronged approach that optimizes drug delivery efficiency and microenvironmental factors that lead to selection pressures.
What You Will Learn
- Modulation of intracellular ceramide using temporal-controlled polymer blend nanoparticles and its effect on overcoming MDR
- Nanoparticle-mediated combination therapy with aerobic glycolytic enzyme inhibition in the treatment of hypoxia-induced resistance in breast cancer
- RNA interference to silence MDR genes and combination therapy in the treatment of ovarian cancer
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The Fine Print
ACS Webinars® does not endorse any products or services. The views expressed in this presentation are those of the presenters and do not necessarily reflect the views or policies of the American Chemical Society.