Nucleic Acids Therapeutics - Making Sense of Antisense
Unmodified oligonucleotides are highly charged, polyanionic macromolecules with poor drug-like properties and a lot of potential. Tune in as Punit Seth of Ionis describes the use of chemical modification strategies to enhance the stability, binding affinity, pharmacokinetic and toxicological properties of oligonucleotide drugs.
What You Will Learn
- General design principles for making an oligonucleotide drug
- Chemical modification strategies to enhance drug-like properties of oligonucleotide drugs
- Recent developments in targeted delivery of oligonucleotide therapeutics
- Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRASin Bladder Cancer Cells through a Decoy Mechanism - ACS Medicinal Chemistry Letters
- Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs - ACS Medicinal Chemistry Letters
- Synthetic Nucleic Acid Delivery Systems: Present and Perspectives - Journal of Medicinal Chemistry
- Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications - Journal of Medicinal Chemistry
The Fine Print
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