Punit Marathe is an Executive Director in the Metabolism and Pharmacokinetics Department at Bristol-Myers Squibb Co. in Princeton, New Jersey. Dr. Marathe has extensive experience in multiple areas of Drug Metabolism and Pharmacokinetics including drug discovery, lead optimization, preclinical and clinical pharmacokinetic studies leading to product registration and life-cycle management. In her current capacity she oversees lead optimization and characterization of drug disposition in the drug discovery stage at four Bristol-Myers Squibb sites.
Dr. Marathe received her Ph.D. degree in Pharmacokinetics from the Department of Pharmaceutics at the University of Washington followed by a postdoctoral fellowship in the Department of Medicinal Chemistry at the same university. She subsequently joined Bristol-Myers Squibb Co. where she held positions of increasing responsibility in both drug discovery and clinical development. Her current responsibilities include collaborating with all therapeutic areas for selection, optimization and characterization of lead candidates for development. Her group conducts pharmacokinetic and metabolism studies from hit identification till the design of First-in-human studies. The group is also responsible for establishing PK-PD relationship for lead molecules in various disease states; projecting human pharmacokinetic profile and efficacious dose for small molecules as well as therapeutic proteins.
Punit has played a critical leadership role in the optimization of nonclinical PK study cycle times and implementation of global sourcing in support of nonclinical PK screening. Her research interests include understanding pharmacokinetic-pharmacodynamic relationships in nonclinical animal models, translation to humans and prediction of human efficacious doses. Dr. Marathe has published over 80 publications and has presented at multiple national and international conferences.