Mark graduated from UC San Diego with a B.S. in chemistry in 2002. He continued studying chemistry at The Scripps Research Institute, earning his doctorate degree under the guidance of Professor Dale Boger in natural product total synthesis in 2007. Since 2007, he has worked as a medicinal chemist at Janssen Research and Development L.L.C. in the Pain and Related Disorders and Immunology therapeutic areas. In 2014, he served as the chair of the San Diego section of the American Chemical Society.