Hadi Valadi’s current research is about RNA transport that occurs between cells, via extracellular vesicles, which are so-called exosomes. In 2003, he received his PhD in Chemistry & Biotechnology from Chalmers technical university, which was about the functional analysis of three isoenzymes (Glyceraldehyde 3-phosphate dehydrogenase) from the upper part of the glycolysis.
As a Postdoctoral Fellow from 2004 through 2008, he joined Professor Jan Lötvall’s group at University of Gothenburg, Institute of Internal Medicine. During this period, they discovered that extracellular vesicles, termed exosomes, transport RNA between cells. The findings suggest a previously undescribed mechanism by which cells send RNA-messages to each other by loading them into exosome-vesicles (Valadi H. et al. Nature Cell Biology 2007).
Since 2008, with funding from the Swedish Research Council, he started his research profile at the Institute of Medicine at the University of Gothenburg. Currently he is studying the transport of RNA that occurs between cells via extracellular vesicles (exosomes) in health and disease and the possibility of using exosomes as a “biological vehicle” to deliver therapeutic RNAs to cells and organs.