Bexarotene

July 30, 2012

Bexarotene is an anticancer agent developed by Ligand Pharmaceuticals and marketed under the trade name Targretin. It was approved by the FDA for treating cutaneous T-cell lymphoma in 1999. The rights to bexarotene were purchased by Eisai in 2006. Recently, G. Landreth and co-workers showed that bexarotene removes amyloid-β protein from the brains of mice with Alzheimer’s disease (AD) and thus restores their memory. Whether this finding can be applied to AD in humans remains to be seen.

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