Clopidogrel, sold under the brand name Plavix, is commonly known as a “blood thinner”. It prevents blood from clotting in patients who are vulnerable to stroke, heart attack, and other vascular diseases. Clopidogrel is actually a prodrug—its thiophene ring hydrolyzes in vivo to the active metabolite. An improved synthesis of the chiral α-amino ester moiety in clopidogrel is described in the June 13, 2011, edition of Noteworthy Chemistry.
Learn more about this molecule from CAS, the most authoritative and comprehensive source for chemical information.
Stay Ahead of the Chemistry Curve
Learn how ACS can help you stay ahead in the world of chemistry.