September 21, 2015

Cyclodextrins are sugar molecules bound together in rings of various sizes. Specifically, the sugar units are called glucopyranosides—glucose molecules that exist in the pyranose (six-membered) ring configuration. Six, 8, or 10 glucopyranosides bind with each other to form α-, β-, and γ-cyclodextrin, respectively. β-Cyclodextrin is shown in the images.

The three cyclodextrins occur naturally; they were first described in 1891 by A. Villiers, who called them “cellulosine”. A few years later, A. Schardinger characterized the three variants.

As complex as they are, cyclodextrins are relatively easy to make. Starch is treated with a combination of common enzymes, notably cyclodextrin glycosyl transferase and α-amylase. Each enzyme combination produces a characteristic ratio of the three cyclodextrins.

Cyclodextrins form a toroid (truncated cone) configuration with multiple hydroxyl groups at each end. This allows them to encapsulate hydrophobic compounds without losing their solubility in water.

Among other applications, cyclodextrins can be used to carry hydrophobic drug molecules into biological systems. Cyclodextrins used in the laundry product Febreze trap odor molecules so that they do not reach the scent receptors in your nose.

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