Ebselen—formally, 2-phenyl-1,2-benzisoselenazol-3(2H)-one—readily scavenges hydrogen peroxide and hydroperoxides in vivo. It was originally developed (and then abandoned) as a drug for stroke patients. In 2012, G. C. Churchill and S. R. Vasudevan at the University of Oxford (UK) discovered that ebselen is an inositol monophosphatase inhibitor and has effects that are similar to lithium in a mouse model of mania. It is currently in clinical trials as a drug for treating bipolar disorder.
Learn more about this molecule from CAS, the most authoritative and comprehensive source for chemical information.
Stay Ahead of the Chemistry Curve
Learn how ACS can help you stay ahead in the world of chemistry.