Humulone and its “cousins” adhumulone, cohumulone, prehumulone, and posthumulone are α-acids found in the resin of hops (Humulus lupulus). They are precursors to iso-α-acids, the predominant contributors to bitterness in beer. H. Bungener isolated humulone from commercial hops in 1886, but it wasn’t until 1970 that D. DeKeukeleire and M. Verzele determined its absolute configuration.
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