Scopolamine & Hyoscyamine

Happy Halloween!
October 21, 2014

Scopolamine (1) and its biochemical precursor hyoscyamine (2) are deadly-nightshade alkaloids that are also found other plants of the Solanaceae family such as mandrake, jimsonweed, and tomato. Hyoscyamine is the enantiomer of the well-known nightshade alkaloid atropine.

Both alkaloids are extremely poisonous and have hallucinogenic effects. (Mandrake is sometimes called “insane root”.) They are anticholinergics, and, when used in small doses, they have medical uses such as treating gastrointestinal disorders. Plant extracts containing them have been used medicinally and ritually since biblical times or earlier.

Scopolamine is used criminally to poison people, not only to murder them but also to make them vulnerable to robbery or rape. Despite its adverse effects, it also has been tried as a “truth drug”. 

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