Molecule of the Week

Omecamtiv Mecarbil

June 6, 2011

Omecamtiv mecarbil, a cardiac-specific myosin activator, is being tested for treating left ventricle systolic heart failure. Myosin is present in “fast” and “slow” ATP-hydrolyzing forms; heart disease patients are often deficient in the fast form. Omecamtiv mecarbil binds to both forms to boost ATP hydrolysis and therefore heart function.

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