Spinosyn A

September 26, 2011

Spinosyn A, along with its almost identical isomer, spinosyn D, is a component of spinosad, a US Environmental Protection Agency–registered insecticide and Food and Drug Administration–registered topical treatment for head lice. The active ingredients are produced by the bacterium Saccharopolyspora spinosa. An enzyme in genes extracted from in this bacterium is the first natural product shown to catalyze the Diels–Alder reaction, a step in spinosyn biosynthesis.

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