News & Research
March 2, 2015 | Journal of Proteome Research
Researchers investigated tuberculosis patients’ urine metabolome to help understand the disease pathophysiology and determine effective diagnosis and treatment methods, specifically host-directed therapy and protective vaccines.
March 5, 2015 | ACS Chemical Neuroscience
Cadmium selenide/zinc sulfide core–shell quantum dots surface-functionalized with a zwitterionic palmitoylated peptide ligand deliver a cell-penetrating lipopeptide to a developing chick’s embryo brain without any apparent toxicity.
March 3, 2015 | Journal of Physical Chemistry B
The authors examined the possible role of the tripeptide glutathione in prebiotic molecular evolution. Glutathione contains a γ-peptide bond, which is more thermodynamically favored than standard α-peptide bonds. In the absence of enzymes during prebiotic times, glutathione was a “survivor” and still performs essential biochemical duties.
March 3, 2015 | Langmuir
A food-grade surfactant, sodium stearoyl lactylate (SSL), is used to prepare ultrastable aqueous foams that also contain calcium carbonate nanoparticles. The foams, with half-lives of ≈40 days, are a proof of concept for potential use in food formulations.
March 2, 2015 | Journal of the American Chemical Society
The fluorescent nucleotide analogue 2-aminopurine is often used in DNA assays, but has a low quantum yield and does not always represent relevant conformations. Another analogue, deoxythienoguanosine, has a higher quantum yield and gives more accurate structural and dynamical data.
March 2, 2015 | Journal of Organic Chemistry
A rhodium(I) catalyst is used to cyclize chiral ethers that contain two double and two triple bonds to optically pure tetracyclic ether-ketones with four additional stereogenic centers. The reaction, run in a CO atmosphere to generate the ketone group, consists of domino Pauson–Khand and Diels–Alder cycloadditions.
February 28, 2015 | Bioconjugate Chemistry
Peptides containing the arginine-glycine-aspartate (RGD) sequence are ideal targeting reagents for tumor diagnosis, imaging, and therapy. This one-step method for synthesizing RGD conjugated gold nanoclusters makes the cyclic RGD molecules perform the roles of reducing, stabilizing, and targeting agents.
February 27, 2015 | Chemistry of Materials
The title of this perspective says it all: “Responsive metal–organic frameworks [MOFs] and framework materials: under pressure, taking the heat, in the spotlight, with friends”. A great deal of research has been conducted on “smart” MOFs that respond to all sorts of stimuli.
February 26, 2015 | Journal of Chemical & Engineering Data
Propylene carbonate (PC) is a solvent used for removing acid gases (H2S and CO2) from gas streams, but it’s important not to dissolve hydrocarbons, especially methane. This work reports the solubility of methane in PC at temperatures from –29 to 100 ºC and pressures from 101 to 11,200 kPa. Methane’s solubility minimum is at ≈60 ºC at all pressures.
February 25, 2015 | ACS Photonics
DNA brick assembly is a good way to create programmable “nanobreadboards” on which chromophores can be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. The authors used DNA nanobreadboards to demonstrate all of these functions by making and operating two excitonic AND logic gates.
February 24, 2015 | Accounts of Chemical Research
Cyanines may be old-fashioned dyes, but their optical properties make them ideal components of near-infrared devices. Their popularity has stimulated extensive quantum mechanical investigations to determine their electronic nature. The most recent advances are reviewed here.
February 23, 2015 | Organic Process Research & Development
Penicillin sulfoxide (PS) is used to produce 7-ADCA, an important nucleus of cephalosporin antibiotics. In this study, the binding energies of water, ethyl acetate, and butyl acetate on specific surfaces of PS were evaluated. The binding energies are strongly associated with the crystal morphology of PS.
February 16, 2015 | ACS Sustainable Chemistry & Engineering
Sewage sludge is a wastewater treatment byproduct that can be converted to carbons for use in environmental remediation. Here, polystyrene foam (another waste material) is coated with sludge and pyrolyzed to form hollow sludge carbons (HSCs). The HSCs efficiently adsorb methylene blue (a surrogate for organic pollutants) from water.
February 16, 2015 | Journal of Physical Chemistry
The often-sluggish aqueous oxygen reduction reaction used in fuel cells is difficult to study because water boils at normal operating temperatures. In this study, boiling is suppressed by operating under pressure. This modification allowed the authors to elucidate the reaction’s kinetics.
February 16, 2015 | Journal of Natural Products
A new tricyclic sesquiterpene, meleucanthin, was isolated from an extract of the leaves and branches of the blackfoot daisy Melampodium leucanthum, along with four known sesquiterpene lactones. All of the compounds showed antiproliferative and cytotoxic efficacy against two prostate cancer cells and HeLa cervical cancer cells.
February 13, 2015 | Journal of Chemical Theory and Computation
The flexibility and dynamics of protein loops are critical for biological events at the molecular level. Molecular dynamics simulations were used to classify 169 loops in 38 proteins into “fast” (correlation times <10 ns), “slow” (100–500 ns), and “static” groups. These results and more are available on a public Web server.
February 12, 2015 | ACS Catalysis
Attempted catalytic oxidative couplings of methane produce mostly CO and CO2. This study shows that the catalytic ability of lanthanum oxycarbonate depends on its morphology. One rod-shaped form promotes methane coupling with 65% selectivity to the desired C2+ compounds.
February 5, 2015 | Molecular Pharmaceutics
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. The authors report the codelivery of sorafenib and curcumin by directed self-assembled nanoparticles to enhance the drugs’ therapeutic effect on HCC.
February 3, 2015 | Environmental Science & Technology Letters
The author’s model predicts that atmospheric processing of combustion aerosols may convert insoluble iron to soluble, bioavailable forms. The model suggests that soluble iron deposition from combustion sources contributes >40% of the total soluble iron deposition over significant portions of southern oceans.
February 2, 2015 | Biochemistry
Misfolding, aggregation, and accumulation of proteins as human apolipoprotein C-II (apoC-II) amyloid fibrils are defining characteristics of diseases such as Alzheimer’s and Parkinson’s. The authors show that specific charge and charge-pair mutations within apoC-II significantly alter its ability to form fibrils.
February 2, 2015 | ACS Applied Materials & Interfaces
Hydrogen gas sensors are made via electron beam deposition of platinum on highly aligned sheets of carbon nanotubes. A platinum thickness of 6 nm gave the highest response to hydrogen (3–33% H2 in air at room temperature). The response decreased at greater or smaller thicknesses.
February 2, 2015 | Organic Letters
In aqueous solution at room temperature, arylsulfinic acids react at the 3-position of indoles to displace hydrogen and produce indol-3-yl aryl sulfoxides. No catalyst or additive is required in this electrophilic substitution reaction. The method can be used to produce biologically active sulfoxides
January 28, 2015 | ACS Medicinal Chemistry Letters
Human respiratory syncytial virus (RSV) is an important pathogens that causes lower respiratory tract infections in infants and young children. Several imidazolepyridine derivatives were synthesized and found to have good potency as RSVs fusion inhibitors.