ACS News Service Weekly PressPac: Wed Oct 17 16:42:03 EDT 2007

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News Items in this Edition

Excess female to male births in Canada linked to chronic dioxin exposure

Almost 90 Canadian communities have experienced a shift in the normal 51:49 ratio of male to female births, so that more girls than boys are being born, according to two studies in the Oct. 1 issue of ACS’ Environmental Science & Technology, a semi-monthly journal. James Argo, who headed the research, attributes this so-called “inverted sex ratio” of the residents in those communities to dioxin air pollutants from oil refineries, paper mills, metal smelters and other sources.

The studies analyzed information in the Environmental Quality Database (EQDB), an inventory of pollution sources, cancer data, and other factors developed for Canadian government research on how early exposure to environmental contaminants affects the health of Canadians. Argo points out that the EQDB enables researchers to pinpoint the location of 126,000 homes relative to any of about 65 air pollution sources-types and the occurrence of cancer among residents of those homes.

Argo focused on air pollutants from those sources and the corresponding incidence of cancer among more than 20,000 residents and 5,000 controls. He identified inverted male sex ratios, sometimes as profound as 46:54 in almost all of the communities. The ratio indicated that more females than males were born, a situation that Argo attributed to chronic exposure of parents to dioxin, based on previous studies. The study “may represent one of only a few studies explicitly designed to identify the impact of carcinogens from industrial sources on residents at home,” Agro stated.

Tiny capers pack big disease-fighting punch

Journal Information

Journal: Environmental Science & Technology

Journal Article: “Chronic Disease and Early Exposure to Air-Borne Mixtures: 1. The Environmental Quality Database” and “Chronic Disease and Early Exposure to Air-Borne Mixtures: 2. Exposure Assessment”

Capers, used in such culinary delights as chicken piccata and smoked salmon, may be small. But they are an unexpectedly big source of natural antioxidants that show promise for fighting cancer and heart disease when added to meals, particularly meats, researchers in Italy are reporting in the current (Oct. 17) issue of ACS’ Journal of Agricultural and Food Chemistry, a bi-weekly publication.

The flower buds of a small bush, capers have been used for centuries in Mediterranean cuisine, where they provide a salty tang and decorative flair to a variety of meats, salads, pastas and other foods. In the new study, Maria A. Livrea and colleagues note that other foods in the so-called Mediterranean diet have gotten plenty of attention for their health benefits. Capers, however, have been largely overlooked.

Their laboratory study involved adding caper extracts to grilled ground-turkey, and analyzing byproducts formed during simulated digestion. The scientists found that caper-extract helped prevent the formation of certain byproducts of digested meat that have been linked by others to an increased risk of cancer and heart disease. That beneficial effect occurred even with the small amounts of caper typically used to flavor food. “Caper may have beneficial health effects, especially for people whose meals are rich in fats and red meats,” the study concluded.

Bacteria in the intestines can influence results of drug tests

Journal Information

Journal: Journal of Agricultural and Food Chemistry

Journal Article: “Bioactive Components of Caper (Capparis spinosa L.) from Sicily and Antioxidant Effects in a Red Meat Simulated Gastric Digestion”

Bacteria living in the intestines of laboratory rats — those test tubes on four feet that stand in for humans in a wide range of research — may influence the results of drug safety and other tests, scientists in Michigan are reporting. The findings are scheduled for the Dec. 7 issue of ACS’ Chemical Research in Toxicology, a monthly journal.

Cynthia M. Rohde and colleagues note growing recognition of the hidden role of the approximately 100 trillion bacteria that thrive in the intestines of humans. Studies have shown that this so-called “gut microflora” can influence the immune system, how the body responds to foods, the action of drugs, and other functions. Researchers started the new study after noting that a genetically identical population of rats widely used in laboratory tests had developed two distinctively different metabolic types. The types involve differences in the way those animals metabolize, or breakdown, drugs and nutrients.

After detailed studies of substances in the urine of the rats, researchers concluded that the differences result from differences in the gut microbial populations between the two types. The report recommends that scientists in the future check lab rat populations for such metabolic differences due to gut microflora in order to assure accurate results, especially in experiments to evaluate the safety of new drugs.

Recycling of e-waste in China may expose mothers, infants to high dioxin levels

Journal Information

Journal: Chemical Research in Toxicology

Journal Article: “Metabonomic Evaluation of Schaedler Altered Microflora Rats”

With China now the destination for 70 percent of the computers, TVs, cell phones, and other electronic waste (e-waste) recycled worldwide each year, a new study has concluded that Chinese recycling methods significantly increase dioxin levels in women and their breast-fed infants. The study is scheduled for the Nov. 15 issue of ACS’ Environmental Science & Technology, a semi-monthly publication.

Ming H. Wong and colleagues did one of what they describe as “very few” studies of dioxin levels among women of child bearing age at an e-waste recycling site, and compared those levels to women in an area without e-waste recycling. They analyzed levels of dioxins — compounds linked to cancer, developmental defects, and other health problems — in samples of breast milk, placenta, and hair.

Samples from the e-waste site showed significantly higher levels of dioxins than those taken at the reference site. Researchers estimated that the daily intake of infants from 6 months of breast feeding at the recycling site was more than double that of the reference site. Therefore, this implies that these levels at the recycling site and the reference site were at least 25 times and 11 times higher, respectively, than the World Health Organization tolerable daily limit for adults regarding dioxins and dioxin-like PCBs. The study includes descriptions of recycling methods, which include heating scrap electronic components over coal fires in the open air.

Chemistry of San Andreas Fault may offer clues to earthquake mysteries

Journal Information

Journal: Environmental Science & Technology

Journal Article: “Body Loadings and Health Risk Assessment of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans at an Intensive Electronic Waste Recycling Site in China”

R Scientists have obtained core samples from deep inside California’s San Andreas Fault for the first time, a finding that may lead to a better understanding of the underground molecular events associated with earthquakes, according to an article scheduled for the Oct. 22 issue of Chemical & Engineering News, ACS’ weekly newsmagazine.

The 800-mile-long fault that bisects California is infamous as the source of the region’s most devastating earthquakes. Conventional sampling of the fault yields slurries of rock chips that are fragmented and difficult to study. In the article, C&EN senior editor Elizabeth K. Wilson describes how new technology borrowed from the oil-drilling industry allows scientists to reach more than 2 miles into the earth to bring up virtually intact core samples from the San Andreas Fault Observatory at Depth in Parkfield, Calif. The core samples will provide an unprecedented picture of the minerals and fluids that are produced at an earthquake source, including new information about the chemistry behind plate movements and fluid flow in fault zones, the writer notes.

“Earthquake scientists around the world have been invited to a “sample party” at Stanford University in December, where they’ll get a chance to inspect the cores and request pieces for them to study,” Wilson writes.

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Journal Information

Journal: Chemical & Engineering News

Journal Article: “Sampling The San Andreas”