First discovery of the female sex hormone progesterone

“Occurrence of Progesterone and Related Animal Steroids in Two Higher Plants”
Journal of Natural Products

In a finding that overturns conventional wisdom, scientists are reporting the first discovery of the female sex hormone progesterone in a plant. Until now, scientists thought that only animals could make progesterone. A steroid hormone, secreted by the ovaries, progesterone prepares the uterus for pregnancy and maintains pregnancy. A synthetic version, progestin, is used in birth control pills and other medications. The discovery is reported in ACS’ Journal of Natural Products, a monthly publication: “Occurrence of Progesterone and Related Animal Steroids in Two Higher Plants.”

“The significance of the unequivocal identification of progesterone cannot be overstated,” the article, by Guido F. Pauli and colleagues, states. “While the biological role of progesterone has been extensively studied in mammals, the reason for its presence in plants is less apparent.” They speculate that the hormone, like other steroid hormones, might be an ancient bioregulator that evolved billions of years ago, before the appearance of modern plants and animals. The new discovery may change scientific understanding of the evolution and function of progesterone in living things.

Scientists previously identified progesterone-like substances in plants and speculated that the hormone itself could exist in plants. But researchers had not found the actual hormone in plants until now. Pauli and colleagues used two powerful laboratory techniques, nuclear magnetic resonance and mass spectroscopy, to detect progesterone in leaves of the Common Walnut, or English Walnut, tree. They also identified five new, progesterone-related steroids in a plant belonging to the buttercup family.

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