"Gingerol Reverses the Cancer-Promoting Effect of Capsaicin by Increased TRPV1 Level in a Urethane-Induced Lung Carcinogenic Model"
Journal of Agricultural and Food Chemistry
For many people, there’s nothing more satisfying than a hot, spicy meal. But some research has suggested that capsaicin, the compound that gives chili peppers their kick, might cause cancer. Now researchers show in mouse studies that the pungent compound in ginger, 6-ginergol, could counteract capsaicin’s potentially harmful effects. In combination with the capsaicin, 6-gingerol could lower the risk of cancer, they say. The study appears in ACS’ Journal of Agricultural and Food Chemistry.
Both chili peppers and ginger are widely used spices in certain cuisines, particularly in Asia, and have been studied for potential health effects. Although some studies have shown that peppers can have benefits, others suggest that diets rich in capsaicin might be associated with stomach cancer. Ginger, however, has shown promise as a health-promoting ingredient. Oddly enough, capsaicin and 6-gingerol both bind to the same cellular receptor — one that is related to tumor growth. Jiahuan Li, Gangjun Du and colleagues wanted to further investigate this apparent contradiction.
Over several weeks, the researchers fed mice prone to lung cancer either capsaicin or 6-gingerol alone, or a combination of both. During the study period, all of the mice that received only capsaicin developed lung carcinomas while only half of the mice fed 6-gingerol did. Surprisingly, an even lower percentage — only 20 percent — of the mice given both compounds developed cancer. The researchers also dug into the potential molecular underpinnings of how the compounds interact to lead to this effect.
The authors acknowledge funding from the National Natural Science Foundation of China.