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ACS News Service Weekly PressPac: July 28, 2021
Recent advances in COVID testing
Since the early days of the COVID-19 pandemic, reverse transcriptase-polymerase chain reaction (RT-PCR) has been the most widely used diagnostic test for the sensitive detection of SARS-CoV-2. However, researchers have made great progress in developing faster, cheaper, simpler and more accurate methods, including ones that can be deployed in resource-limited settings. Below are some recent papers published in ACS journals that report on advances in COVID testing.
“Hyperspectral Mapping for the Detection of SARS-CoV-2 Using Nanomolecular Probes with Yoctomole Sensitivity”
July 19, 2021
In this paper, researchers report development of an ultrasensitive hyperspectral sensor based on hafnium nanoparticles for the detection of SARS-CoV-2. The assay, which can be completed in a few seconds, can detect the virus at a concentration 1 million times lower than currently available tests, with 100% specificity. The outstanding sensitivity suggests that the biosensor could be useful in diagnosing pre-symptomatic and asymptomatic COVID-19 cases, the researchers say.
“Dye-Loaded Polymersome-Based Lateral Flow Assay: Rational Design of a COVID-19 Testing Platform by Repurposing SARS-CoV-2 Antibody Cocktail and Antigens Obtained from Positive Human Samples”
July 16, 2021
Researchers repurposed SARS-CoV-2-specific antigens and antibodies from patient samples to develop a lateral flow assay for the naked-eye detection of the virus. The test is economical and suitable for use in resource-limited settings, the scientists say.
“Multichannel Immunosensor Platform for the Rapid Detection of SARS-CoV-2 and Influenza A(H1N1) Virus”
ACS Applied Materials & Interfaces
May 9, 2021
COVID-19 and influenza A can have similar symptoms, so researchers developed a point-of-care test that could quickly and simultaneously test for both viruses. The multichannel electrochemical immunoassay showed a broader linear range, comparable sensitivity and much higher specificity than the commonly used enzyme-linked immunosorbent assay (ELISA).
“Rapid Detection of COVID-19 Using MALDI-TOF-Based Serum Peptidome Profiling”
March 3, 2021
Mass spectrometry combined with machine learning quickly detected SARS-CoV-2 from peptides in patients’ serum, with 98% sensitivity and 100% specificity. The high-throughput method has great potential for screening, routine surveillance and diagnosis of COVID-19 in large populations, the researchers say.
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