Live Online
Nov 12, 2025 | 11:00 AM–12:00 PM EST
1 hr
Biological & Medicinal Chemistry
Safety
Analytical Chemistry
Despite decades of research, drug–drug interactions continue to undermine treatment outcomes. They affect more than 10% of patients in some populations and account for up to 30% of hospitalisations linked to adverse drug reactions.
In this webinar, Professor Tore Stage will use isoxazolyl penicillins as a case study to demonstrate an integrated framework for evaluating drug-drug interactions, showing how dicloxacillin and flucloxacillin act as metabolic inducers with clinically significant consequences.
To uncover these effects, the project combined complementary methods: hepatocyte cultures in 2D and 3D formats with qPCR and LC–MS/MS analysis, pharmacokinetic studies in healthy volunteers using a probe–drug cocktail design, and register-based studies to assess real-world outcomes. Together, these approaches form a transferable model for evaluating drug-drug interactions from bench to clinic.
Tore B Stage
Head of Research, Professor of Clinical Pharmacology, Pharmacy and Environmental Medicine, The University of Southern Denmark
Dr. Joe Lackey
Technical Manager, LGC Standards
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