C&EN Webinar

Session 2: Ion-Pairing Free LC/MS Analysis of Oligos: HILIC and RP

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DETAILS:

Live virtual event

Feb 19, 2025 | 10–11 AM ET

60 minutes

TOPICS:

Analytical Chemistry
Biological & Medicinal Chemistry

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This webinar will delve into the limitations of traditional Ion Pairing Reversed Phase (IP-RP) chromatography, particularly its high costs, environmental impact, and need for specialized equipment. We will explore Hydrophilic Interaction Chromatography (HILIC) as a promising alternative, highlighting its compatibility with mass spectrometry (MS) and the absence of ion-pairing reagents, which offers greater flexibility in instrumentation.

Additionally, we’ll discuss recent advancements in ion pairing-free RP approaches for oligonucleotide analysis using LC/MS, showcasing studies on a range of oligonucleotides from 14mer to 103mer. Key parameters for optimizing LC/MS performance in these methods will also be covered.

Speakers

Connor Flannery

Global Product Manager HPLC Bio Columns, Agilent Technologies

Lee Bertram

Application Scientist, Agilent Technologies

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