Opportunity Description:

We are seeking a self-motivated postdoctoral fellow to work on the Tox21 research projects in development of physiologically relevant assays for assessment of environmental chemicals. The NCATS has a unique and exciting environment employing state-of-art technologies on assay development, chemical screening, and profiling for toxicology research. The fellow will develop in vitro cell-based assays using physiologically relevant cell models (primary cells, stem cell/iPS-derived cells, and 3-D cell/organoid models) with biotransformation-capability for screening chemicals. The fellow will apply new technologies including 3-D cell/organoid models and high content phenotypic profiling using cell-based imaging assays for evaluating chemical toxicity. The fellow will perform follow-up studies (e.g., mechanisms of compound action) after the primary screening. The fellow will also interact regularly with informatics scientists to aid data analysis and interpretation.