Opportunity Description:

Available immediately for highly motivated recent PHDs in Chemical Biology, or Organic/Medicinal Chemistry to join a multidisciplinary team involved in developing innovative immunotherapies to treat cancer and viral infections. For examples of our multidisciplinary research and technologies used in our work, see https://ranalab.ucsd.edu ; https://pubmed.ncbi.nlm.nih.gov/?term=rana+tm; and representative publications: Nature Biotechnology, 2008, 26, 1187; J Med Chem, 2016, 59, 7677; JACS, 2016, 138, 6068; ACS Chemical Biology 2021, https://doi.org/10.1021/acschembio.0c00841; J Med Chem, 2021, https://doi.org/10.1021/acs.jmedchem.1c00566, J Med Chem, 2022, https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.1c02075, Cancer Research Comm, 2023, https://aacrjournals.org/cancerrescommun/article/3/1/119/716125/Small-molecule-PTPN2-Inhibitors-Sensitize . Projects include synthesis and activity analysis of new compounds, enzyme inhibition assays, antibody-drug conjugates, lipid nanoparticles for RNA vaccines and gene delivery, design and synthesis of chemical probes to investigate RNA functions, and formulation of drug candidates for sustained in vivo delivery. Candidates with strong chemical biology or organic chemistry, SAR/lead optimization, and drug formulation training are preferred. Strong publication record and training to perform independent research are required for further consideration. Successful Candidate will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities.