Azelastine hydrochloride

December 31, 2018
Take me for your runny nose and teary eyes.
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Azelastine hydrochloride (HCl) is an antihistamine administered in aqueous solution as a nasal spray. It exhibits histamine H1 receptor antagonist activity and is used as a racemic mixture. No difference in pharmacologic activity between its enantiomers has been observed.

Azelastine HCl is used to treat seasonal allergic rhinitis (e.g., hay fever) and perennial rhinitis (including runny nose, sneezing, and nasal itching). It is also used in eyedrops to treat allergic conjunctivitis. It is considered to be a very safe drug with no serious side effects.

Azelastine HCl has been known since 1980, but its first US Food and Drug Administration approval for use as a nasal spray was awarded to Meda Pharmaceuticals (Somerset, NJ) under the brand name Astepro in 2008. Since its first registration, the drug has been sold under many brand names and is now generic.

Azelastine hydrochloride hazard information

GHS classification*: acute toxicity, oral, category 4
H302—Harmful if swallowedChemical Safety Warning

*Globally Harmonized System of Classification and Labeling of Chemicals. Explanation of pictograms.

Azelastine hydrochloride fast facts

CAS Reg. No.79307-93-0
Empirical formulaC22H24ClN3OHCl
Molar mass418.36
AppearanceWhite crystalline powder
Melting point225–229 ºC
Water solubility35 mg/L
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