ACS News Service Weekly PressPac: September 03, 2014

Information Resources on Ebola

Ebola has so far infected thousands of people in 2014, making it the largest outbreak of the virus in history. Despite the incredible efforts of local and global public health teams, Tom Frieden, the director of the Centers for Disease Control and Prevention, called the situation “unprecedented” while on a visit to the affected region. He also predicted that it would only get worse before officials could get a handle on the crisis.

In addition to governments and businesses, scientists play a major part in stemming any infectious disease outbreak, including the current one.

This resource page includes a list of scientific papers, as well as Chemical & Engineering News articles, on Ebola that journalists can access for free. The page also includes a list of experts who can speak about this topic to the press.

ACS Research Papers

(free access until February 28, 2015)

A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection. Molecular Pharmaceutics (2014), DOI: 10.1021/mp500646d, Choi, Jin Huk; Jonsson-Schmunk, Kristina; Qiu, Xiangguo; Shedlock, Devon J; Strong, Jim; Xu, Jason X; Michie, Kelly L; Audet, Jonathan; Fernando, Lisa; Myers, Mark j; Weiner, David B.; Bajrovic, Irnela; Tran, Lilian Q; Wong, Gary; Bello, Alexander; Kobinger, Gary P; Schafer, Stephen C; Maria A. Croyle.

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function. Journal of Proteome Research (2014), DOI: 10.1021/pr500556d, García-Dorival, Isabel; Wu, Weining; Dowall, Stuart; Armstrong, Stuart; Touzelet, Olivier; Wastling, Jonathan; Barr, John N.; Matthews, David; Carroll, Miles; Hewson, Roger; Hiscox, Julian A.

Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge. ACS Chemical Biology (2014), DOI: 10.1021/cb5006454, Chen, Gang; Koellhoffer, Jayne F.; Zak, Samantha E.; Frei, Julia C.; Liu, Nina; Long, Hua; Ye, Wei; Nagar, Kaajal; Pan, Guohua; Chandran, Kartik; Dye, John M.; Sidhu, Sachdev S.; Lai, Jonathan R.

Digital Sensing and Sizing of Vesicular Stomatitis Virus Pseudotypes in Complex Media: A Model for Ebola and Marburg Detection. ACS Nano (2014), 8(6), 6047-6055, DOI: 10.1021/nn501312q, Daaboul, George G.; Lopez, Carlos A.; Chinnala, Jyothsna; Goldberg, Bennett B.; Connor, John H.; Unlu, M. Selim.

A Multistage Volumetric Bar Chart Chip for Visualized Quantification of DNA. Journal of the American Chemical Society (2013), 135(45), 16785-16788, DOI: 10.1021/ja4085397, Song, Yujun; Wang, Yuanchen; Qin, Lidong.

Development of RNA Aptamers Targeting Ebola Virus VP35. Biochemistry (2013), 52(47), 8406-8419, DOI: 10.1021/bi400704d, Binning, Jennifer M.; Wang, Tianjiao; Luthra, Priya; Shabman, Reed S.; Borek, Dominika M.; Liu, Gai; Xu, Wei; Leung, Daisy W.; Basler, Christopher F.; Amarasinghe, Gaya K.

Fine Modulation of the Respiratory Syncytial Virus M2-1 Protein Quaternary Structure by Reversible Zinc Removal from Its Cys3-His1 Motif. Biochemistry (2013), 52(39), 6779-6789, DOI: 10.1021/bi401029q, Esperante, Sebastian A.; Noval, Maria G.; Altieri, Tamara A.; de Oliveira, Guilherme A. P.; Silva, Jerson L.; de Prat-Gay, Gonzalo.

Modeling Pre-Existing Immunity to Adenovirus in Rodents: Immunological Requirements for Successful Development of a Recombinant Adenovirus Serotype 5-Based Ebola Vaccine. Molecular Pharmaceutics (2013), 10(9), 3342-3355, DOI: 10.1021/mp4001316, Choi, Jin Huk; Schafer, Stephen C.; Zhang, Lihong; Juelich, Terry; Freiberg, Alexander N.; Croyle, Maria A.

Conformational Properties of Peptides Corresponding to the Ebolavirus GP2 Membrane-Proximal External Region in the Presence of Micelle-Forming Surfactants and Lipids. Biochemistry (2013), 52(20), 3393-3404, DOI: 10.1021/bi400040v, Regula, Lauren K.; Harris, Richard; Wang, Fang; Higgins, Chelsea D.; Koellhoffer, Jayne F.; Zhao, Yue; Chandran, Kartik; Gao, Jianmin; Girvin, Mark E.; Lai, Jonathan R.

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe. ACS Medicinal Chemistry Letters (2013), 4(2), 239-243, DOI:  10.1021/ml300370k, Lee, Kyungae; Ren, Tao; Cote, Marceline; Gholamreza, Berahman; Misasi, John; Bruchez, Anna; Cunningham, James.

Glycofullerenes Inhibit Viral Infection. Biomacromolecules (2013), 14(2), 431-437, DOI: 10.1021/bm3016658, Sanchez-Navarro, MacArena; Ribeiro-Viana, Renato; Ginieis, Anthony; Rojo, Javier; Luczkowiak, Joanna; Delgado, Rafael; Munoz, Antonio; Illescas, Beatriz M.; Martin, Nazario (correspondence); Martin, Nazario (correspondence).

Crystal Structure of the Marburg Virus GP2 Core Domain in Its Postfusion Conformation. Biochemistry (2012), 51(39), 7665-7675, DOI: 10.1021/bi300976m, Koellhoffer, Jayne F.; Malashkevich, Vladimir N.; Harrison, Joseph S.; Toro, Rafael; Bhosle, Rahul C.; Chandran, Kartik; Almo, Steven C.; Lai, Jonathan R.

Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain α-Helical Bundle. Biochemistry (2012), 51(12), 2515-2525, DOI: 10.1021/bi3000353, Harrison, Joseph S.; Koellhoffer, Jayne F.; Chandran, Kartik; Lai, Jonathan R.

A Single Sublingual Dose of an Adenovirus-Based Vaccine Protects against Lethal Ebola Challenge in Mice and Guinea Pigs. Molecular Pharmaceutics (2012), 9(1), 156-167, DOI: 10.1021/mp200392g, Choi, Jin Huk; Schafer, Stephen C.; Zhang, Lihong; Kobinger, Gary P.; Juelich, Terry; Freiberg, Alexander N.; Croyle, Maria A.

Pseudosaccharide Functionalized Dendrimers as Potent Inhibitors of DC-SIGN Dependent Ebola Pseudotyped Viral Infection. Bioconjugate Chemistry (2011), 22(7), 1354-1365 DOI: 10.1021/bc2000403, Luczkowiak, Joanna; Sattin, Sara; Sutkeviciute, Ieva; Reina, Jose Juan; Sanchez-Navarro, Macarena; Thepaut, Michel; Martinez-Prats, Lorena; Daghetti, Anna; Fieschi, Franck; Delgado, Rafael; Bernardi, Anna; Rojo, Javier.

A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus. Journal of Medicinal Chemistry (2011), 54(5), 1157-1169, DOI: 10.1021/jm100938u, Opsenica, Igor; Burnett, James C.; Gussio, Rick; Opsenica, Dejan; Todorovic, Nina; Lanteri, Charlotte A.; Sciotti, Richard J.; Gettayacamin, Montip; Basilico, Nicoletta; Taramelli, Donatella; Nuss, Jonathan E.; Wanner, Laura; Panchal, Rekha G.; Solaja, Bogdan A.; Bavari, Sina.

Discovery, Synthesis, and Biological Evaluation of a Novel Group of Selective Inhibitors of Filoviral Entry. Journal of Medicinal Chemistry (2011), 54(3), 765-781, DOI: 10.1021/jm1008715, Yermolina, Maria V.; Wang, Ji-Zhen; Caffrey, Michael; Rong, Li-Jun L.; Wardrop, Duncan J.

An Optofluidic Nanoplasmonic Biosensor for Direct Detection of Live Viruses from Biological Media. Nano Letters (2010), 10(12), 4962-4969, DOI: 10.1021/nl103025u, Yanik, Ahmet A.; Huang, Min; Kamohara, Osami; Artar, Alp; Geisbert, Thomas W.; Connor, John H.; Altug, Hatice.

Inhibiting HIV Fusion with a β-Peptide Foldamer. Journal of the American Chemical Society (2005), 127(38), 13126-13127, DOI: 10.1021/ja053444+, Stephens, Olen M.; Kim, Sunghwan; Welch, Brett D.; Hodsdon, Michael E.; Kay, Michael S.; Schepartz, Alanna.

Recent C&EN News Stories

Experts on Ebola, Infectious Diseases and Biosafety

For information on Ebola:

Yoshi Kawaoka, Ph.D., D.V.M.
School of Veterinary Medicine
University of Wisconsin – Madison

Charles Arntzen, Ph.D.
The Biodesign Institute, Infectious Diseases and Vaccinology
Arizona State University

For information on infectious diseases, including Ebola:

Michael Osterholm, Ph.D., M.P.H.
University of Minnesota
Director of Center for Infectious Disease Research and Policy (CIDRAP)

Craig W. Lindsley, Ph.D.
Editor-in-chief, ACS Chemical Neuroscience
Co-Director, Vanderbilt Center for Neuroscience Drug Discovery
Director, Medicinal Chemistry

For general information about infectious diseases:

Andrew Read, Ph.D.
Director, Center for Infectious Disease Dynamics
The Pennsylvania State University

For information about biosafety:

Denise Aronson
President, Safety Partners, Inc.

Additional Resources

For more on Ebola, keep an eye out for the American Chemical Society’s new journal ACS Infectious Diseases, which will publish its first issue January 2015. “Our journal will play a role in this devastating disease by publishing basic research on new antivirals for Ebola,” says Courtney Aldrich, editor-in-chief.

The research papers were compiled using a search strategy created and conducted by Science IP®, the CAS Search Service.

Why Isn't There a Cure for Ebola Yet? — This infographic explains it's because drug development takes a lot of research, money and time.
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