C&EN Webinar

Analyzing Protein Developability and Stability at High-Throughput

Watch On Demand


On-demand virtual event


Analytical Chemistry
Biological & Medicinal Chemistry

Understanding the biophysical state, quality and properties of biopharmaceuticals is essential in product and process development. However, available material, time and resources are often limiting.

Dynamic light scattering (DLS) is an industry standard technique for protein formulation, particle sizing and stability studies. This webinar will illuminate how high-throughput DLS (HT-DLS), performed in low-volume microwell plates, is used to understand aggregation as well as colloidal and thermal stability of therapeutic protein candidates and formulations. Application examples include various studies of freeze-thaw, formulation buffer screening and thermal stability.

Key Learning Objectives:

  • Background and instrumentation for HT-DLS
  • How DLS is used to study aggregation under applied stresses
  • How DLS evaluates protein colloidal stability via second virial coefficient A2 and the diffusion interaction parameter kD.

Who Should Attend:

  • Biopharma product development scientists in need of automated methods for characterizing protein stability
  • Formulation lab managers seeking to improve productivity with high-throughput DLS instrumentation


Felix Gloge, Ph.D.

Field Application Scientist, Wyatt Technology

Christian Sieg, Ph.D.

Application Scientist, Wyatt Technology

Melissa O'Meara

Forensic Science Consultant, C&EN Media Group

ACS Institute

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