We're kicking things off with a bang in 2016! Join us as Robert Copeland starts things off with a look at the importance of target conformational dynamics and its impact on drug affinity. The drug-target residence time model will be introduced and its applications in drug design will be reviewed.
What You Will Learn
- The kinetic and equilibrium differences between closed and open systems and how these affect drug-target interactions in vitro and in vivo.
- The impact of drug-dissociation rates and drug-target residence time on in vivo pharmacology.
- Examples of the application of the drug-target residence time model to lead optimization.
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The Fine Print
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