Dealing with Reactive Drug Metabolites in Drug Discovery: Can We Predict Toxicities of Drug Candidates that form Reactive Metabolites?

ACS Webinars

A perceived notion of reactive metabolite formation as a standalone predictor of toxicity risks may be over exaggerated and that other factors such as body burden of the reactive moiety may be a better predictor. Join Deepak Dalvie of Pfizer as he discusses pragmatic risk mitigation strategies and the path forward for drug candidates that carry a RM liability.

What You Will Learn

  • How we can confront reactive drug metabolites in drug discovery
  • Can we predict reactive metabolite forming drugs, why or why not
  • Practical strategies to manage reactive metabolites


The Fine Print

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Deepak Dalvie

Frederick Peter Guengerich
Vanderbilt University

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