CRISPR systems: Nature's toolkit for genome engineering

The Fred Kavli Innovations in Chemistry Lecture

Presented by Jennifer Doudna

Abstract

Facile genome manipulation using precision DNA and RNA recognition is transforming biology. Understanding the underlying chemical mechanisms of RNA-guided DNA and RNA cleavage provides a foundation for both conceptual advances and technology development. I will discuss how bacterial CRISPR adaptive immune systems inspire creation of powerful genome engineering tools, enabling advances in both fundamental biology and applications in medicine and agriculture.