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Bioconjugation in Polymer Chemistry

ACS Webinars
A carabiner connecting two ropes

Biomacromolecules, including proteins, enzymes, and antibodies, are the workhorses of living systems and the foundation of breakthrough technologies in medicine, energy, sustainability, and food processing. Currently, what is our ability to rationally design “Molecular Chimeras” to bring together proteins and synthetic polymers?

Furthermore, polymers that assemble with nucleic acids into nanocomplexes (polyplexes) have been widely examined for many fundamental biological and applied biomedical applications. However, understanding the binding, encapsulation, and intracellular transport mechanisms and in vivo efficacy of these vehicles remains a major hurdle in their effective usage and translation.

Join Coray Colina of the University of Florida and Theresa Reineke of the University of Minnesota during this free interactive 1.5 hour broadcast as they discuss what makes these polymeric structures so unique and share how molecular simulations are helping to elucidate the structure, function, and dynamics of such molecular chimeras. This ACS Webinar is moderator by Laura Stratton of Polymer Chemistry Innovations and co-produced with the ACS Division of Polymer Chemistry.

What You Will Learn

  • How biological performance significantly influenced by the bioconjugation architecture
  • Why noncovalent conjugation is a stable way to assemble polymers with biological payloads
  • State-of-the-art of molecular simulations for bioconjugation
  • The effect of a variety of polymer architectures (PEGylated and beyond), grafting densities and polymer lengths on the bioconjugates structure, dynamics and function


Coray Colina
University of Florida

Theresa Reineke
University of Minnesota
ACS Macro Letters

Laura Stratton
Polymer Chemistry Innovations