Only about 4% of candidate drugs reach the market. The main culprits of this failure are due to issues with dosing , exposure and toxicity. Join us as Dr. Paul Leeson shares how improving candidate quality can be facilitated by the selection of lead-like chemical starting points, control of physicochemical properties during optimization, employment of predictive chemistry tools, and the application of ligand efficiency measures.
What You Will Learn
- Impact of compound quality on clinical pipeline attrition
- Lead-like versus drug-like physicochemical properties
- Application of ligand efficiency measures in optimization and candidate selection
The Fine Print
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