Mass Spectrometry Made Simple; or, How to Weigh a Molecule (Even Though There Isn’t a Way to Weigh a Molecule)

ACS Webinars

What does an exploding car and a motorboat have in common with mass spectrometry?

Lee Polite of Axion Anyaltical Labs and his entertaining analogies return to ACS Webinars for another journey through the world of mass spectrometry! Mass spectrometry is one of the most important analytical tools available to scientists, but many chemists feel its complexity is beyond understanding. From the fundamentals to quadrupoles to GCMS to LCMS to triple quadrupoles, he will explain how these different instruments work, how best to choose the most appropriate tool for a specific application, and break down this seemingly complex topic into simple steps appropriate for scientists at all levels of experience!

This ACS Webinar is moderated by Bryan Tweedy of the American Chemical Society and co-produced with the Office of Career and Professional Education.

What You Will Learn

  • The fundamental operation of a mass spectrometer, the world’s most powerful identification tool 
  • Why GC/MS is the single best approach for identifying most unknowns, while LC/MS/MS is by far the most sensitive instrument on the market 
  • How to differentiate among the various instrument choices

Additional Resources

  • LC/GC Bootcamp: Hands-On Chromatography Master Class - Join Lee Polite for a week in person as he teaches you everything you need to know to operate HPLCs and/or GCs, develop methods and troubleshoot! 18 lectures on chromatography theory and applications accompany 12 hands-on labs. You will disassemble, assemble and experiment with the dozens of HPLCs and GCs in our laboratory. The course includes time for breaks, networking and other energy boosting activities. 

Co-produced With


What an attendee said about this ACS Webinar!

Great science, great presentation, great fun! I work with mass spectrometry - this was one of the best explanations ever!

Meet the Experts

Lee N. Polite
President and Founder, Axion Analytical Labs, Inc.

Bryan Tweedy
Assistant Director, ACS Education, Office of Career and Professional Education, American Chemical Society

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