Amlexanox, sold under the trade name Aphthasol, is an anti-inflammatory drug that is used to treat canker sores, asthma, and other conditions. It was first patented for use against canker sores in 1994.
Recently, A. R. Saltiel and co-workers at the University of Michigan (Ann Arbor) found that amlexanox is a promising treatment for type 2 diabetes and obesity. They showed that it inhibits two kinases in mice that are produced in the liver and fat in response to inflammation caused by a high-fat diet. Obese mice treated with amlexanox lost weight and became less insulin resistant.
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