Calcitriol, or 1,25-dihydroxycholecalciferol, is the biologically active metabolite of vitamin D3. Its existence and activity were first described by several research groups in the early 1970s. It improves calcium transport in the blood and absorption of calcium from the blood to bones. More recently, Calcitriol’s role in immune system defenses was elucidated by C. Geisler and co-workers.
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