October 19, 2009
Image of Haplophytine 3D Image of Haplophytine

Haplophytine is an insecticidal alkaloid that has been used since Aztec times. It was first isolated from the Mexican plant Haplophyton cimicidum by H. R. Snyder and co-workers in 1951. Its structure was determined by a research team led by P. Yates in 1967; but its total synthesis (in 29 steps!) wasn’t achieved until T. Fukuyama, H. Tokuyama, and colleagues reported it this year.

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