Heme, a porphyrin derivative, is the color component of hemoglobin, which is responsible for transporting oxygen in blood. It was isolated by E. Bertin-Sans and J. de Moitessier in 1892. In 2010, M. P. Soares and coauthors reported that infections can release free heme from hemoglobin, which leads to heme-promoted tissue damage and severe sepsis.
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