CAS REGISTRY Keeps Pace with Rapid Growth of Chemical Research, Registers 60 Millionth Substance

Therapeutic substance originates from Chinese patent, signifying role of Pacific Rim research in the field of chemical and scientific publishing

COLUMBUS, Ohio, May 23, 2011 — Chemical Abstracts Service (CAS), the world’s leader in chemical information and a division of the American Chemical Society (ACS), announced today that a patent application claiming compounds with potential therapeutic activity, submitted to the State Intellectual Property Office of the People’s Republic of China (SIPO), included the 60 millionth substance recorded in the CAS REGISTRY.

CAS observed in 2009 that China surpassed all other nations as the top producer of chemical patent applications. China still maintains the lead today, and finding that the 60 millionth substance registered is from a SIPO application reconfirms that observation.

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Coming less than two years after CAS REGISTRY crossed the 50 million mark, this second major milestone shows the continued acceleration of chemical and scientific output across the globe. CAS scientists keep up with this growth daily, by analyzing, organizing, and curating the output of worldwide research in their native languages to maintain the completeness and quality of CAS’ premier substance collection.

The 60 millionth substance, a potential antiviral compound, was assigned the CAS Registry Number® 1298016-92-8. The substance was discovered by the Institute of Materia Medica, Chinese Academy of Medical Sciences, which is one of the key drug research institutions in China. In the patent application, a team of inventors prepared derivatives of 2-amino-1,3,4-thiadiazine.

60 millionth substance

“It seems fitting that the 60 millionth substance in CAS REGISTRY would originate from within an Asian country, given the region’s growing and significant impact on scientific discovery in recent years,” said Christine McCue, Vice President of Marketing at CAS. “This growth is illustrated not only in the patent arena, but also with respect to journal literature, and led CAS to expand coverage of Asian chemistry through the analysis of more than 300 additional journal titles in the past three years from China, Japan, and Korea alone.”

CAS REGISTRY is the most comprehensive collection of disclosed chemical substance information in the world. It contains more than 60 million unique organic and inorganic substances, such as alloys, coordination compounds, minerals, mixtures, polymers, and salts, and more than 62 million sequences.

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CAS, a division of ACS, is the world’s authority for chemical information. Its databases are curated and quality-controlled by CAS scientists, and recognized by chemical and pharmaceutical companies, universities, government organizations, and patent offices around the world as authoritative. By combining these databases with advanced search and analysis technologies (SciFinder®, STN®, and Science IP® products and services), CAS delivers the most current, complete, and cross-linked digital information environment for scientific discovery. Learn more at

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View the infographic outlining of the he growth of CAS REGISTRY and information on the 60 millionth substance.