Passive Permeability—An Important Mechanism for Drug Absorption

ACS Webinars
A woman's face with a digital image of a brain overlaid on it.

Passive diffusion plays an essential role in oral absorption of drugs through the gastrointestinal tract, penetration across the blood-brain barrier to reach Central Nervous System disease targets, entry into hepatocytes to be metabolized, and drug reabsorption from renal tubules. Passive diffusion and transporters coexist to affect drug disposition.

Join Research Fellow Li Di of Pfizer during this free interactive broadcast as she discusses why design principles that increase passive permeability are effective approaches to increase oral bioavailability, enhance brain penetration, and reduce renal clearance.

What You Will Learn

  • The critical role of passive permeability in drug design 
  • How physicochemical properties influence passive permeability 
  • How passive permeability and transporters coexist to affect ADME properties of drugs


The Fine Print

ACS Webinars® does not endorse any products or services. The views expressed in this presentation are those of the presenters and do not necessarily reflect the views or policies of the American Chemical Society.

ACS Webinars Logo

Meet the Experts

Li Di

Faraj Atassi
Astra Zeneca

Related Articles