What molecule am I?
March of this year was “Solvent Month” for Molecule of the Week. Another commonly used solvent is 1,4-dioxane, usually referred to simply as dioxane.1 It is a cyclic diether that has an odor similar to that of its more volatile cousin, diethyl ether.
In 1928, IG Farbenindustrie (precursor to BASF) patented a manufacturing process for dioxane in which diethylene glycol is heated with a small amount of sulfuric acid. Today, it is still produced in much the same way. It is used industrially as a solvent for cellulose esters and ethers, adhesives, inks, and many other materials.
Dioxane, however, is coming under regulatory pressure because of health and environmental concerns:
- A suspected carcinogen, dioxane has been found to contaminate drinking water in 27 US states.
- Significant amounts of the solvent have been found in groundwater in New York State, prompting a bill in the legislature that would ban it in cleaning and personal care products.
- The US Occupational Safety and Health Administration is considering regulating worker exposure to dioxane.
1. Structural isomers 1,2- and 1,3-dioxane have been prepared, but they are not commercial products.
1,4-Dioxane hazard information
|GHS classification*: flammable liquids, category 2|
|H225—Highly flammable liquid and vapor|
|GHS classification: serious eye damage/eye irritation, category 2A|
|H319—Causes serious eye irritation|
|GHS classification: specific target organ toxicity, single exposure, respiratory tract irritation, category 3|
|H335—May cause respiratory irritation|
|GHS classification: carcenogenicity, category 2|
|H351—Suspected of causing cancer|
1,4-Dioxane fast facts
|CAS Reg. No.||123-91-1|
|Molar mass||88.11 g/mol|
|Melting point||11.8 ºC|
|Boiling point||101.1 ºC|
January 18, 2021
Dioxane is a valuable solvent that has many industrial and laboratory uses. In 2019, it came under regulatory pressure because it is a possible carcinogen and has been found in drinking water and groundwater in several states. On December 31, 2020, the US Environmental Protection Agency released a hastily compiled risk assessment of dioxane that pleased neither environmentalists, state attorneys general, nor the chemical industry. Among the report’s other shortcomings, EPA ignored drinking-water exposure; environmentalists and regulators say that this is dioxane’s greatest threat to the general population.
Learn more about this molecule from CAS, the most authoritative and comprehensive source for chemical information.
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