Carbon nitride

January 16, 2023
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Carbon nitride (C3N4), like elemental carbon, has several stable allotropes. The two most common are β-C3N4 (partial structure shown), which is analogous to diamond, and g-C3N4, whose properties are more like graphite.

In the late 1980s, theoretical physicists Amy Y. Liu at the University of California, Berkeley, and Marvin L. Cohen at Lawrence Berkeley Laboratory predicted that β-C3N4 would have short, strong bonds and could be harder than diamond. The material proved to be difficult to synthesize; but in 1993, Chunming Niu, Yuan Z. Lu, and Charles M. Lieber* at Harvard University (Cambridge, MA) created thin films of β-C3N4 using pulsed laser ablation of graphite targets combined with an intense atomic nitrogen source.

Also in 1993, Wolfgang Schnick at the University of Bayreuth (Germany) reviewed the theoretical and synthetic literature on β-C3N4; and, like Liu and Cohen, he surmised that the substance would be harder than diamond. But 30 years later, this prediction has not been demonstrated. It has been shown, however, that the bulk modulus (resistance to compression) of β-C3N4 is similar to that of diamond.

g-C3N4, as might be expected, consists largely of planar molecular units, mostly heptazines (condensed s-triazines). It usually contains a small amount of hydrogen at the peripheries of these structures. In 2008, Markus Antonietti and coauthors at the Max Planck Institute of Colloids and Interfaces (Golm, Germany) and the Fritz Haber-Institute of the Max Planck-Society (Berlin) reported that g-C3N4 can be made by polymerizing small C–N molecules such as cyanamide, dicyandiamide, and melamine. The researchers showed that the graphitic compound’s semiconductor properties give it “unexpected” catalytic activity for a variety of organic reactions.

Subsequently, several research teams found that g-C3N4 is a powerful photocatalyst. Much of this work is summarized in excerpts from the 2021 book Materials Science in Photocatalysis. If you want to learn even more, read “A Tour-Guide through Carbon Nitride-Land” (2021) by Vincent Wing-hei Lau at Korea University (Seoul) and Bettina V. Lotsch at the Max Planck Institute for Solid State Research (Stuttgart, Germany).


Graphitic carbon nitride hazard information

Hazard class* GHS code and hazard statement
Serious eye damage/eye irritation, category 2A H319—Causes serious eye irritation Chemical Safety Warning
Specific target organ toxicity, single exposure, respiratory tract irritation, category 3 H335—May cause respiratory irritation Chemical Safety Warning

*Globally Harmonized System (GHS) of Classification and Labeling of Chemicals. Explanation of pictograms

Molecule of the Future

Oteseconazole1 is a fluorinated tetrazole derivative used to treat chronic vaginal yeast infections. The US Food and Drug Administration approved it under the trade name Vivjoa in April 2022. According to the manufacturer, Mycovia Pharmaceuticals (Durham, NC), it is the only FDA-approved medication for this condition. Mycovia is also in Phase 2 studies on oteseconazole for treating onychomycosis, a fungal nail infection.

1. CAS Reg. No. 1340593-59-0.

Oteseconazole

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Carbon nitride fast facts

CAS Reg. No. 143334-20-7
SciFinder nomenclature Carbon nitride
Empirical formula C3N4
Molar mass 92.06 g/mol
Appearance Off-white to yellowish-brown crystals or powder
Melting point

β-C3N4: 2950 °C

g-C3N4: 600–700 °C (dec.)

Water solubility Insoluble

MOTW update

Sulfoxaflor1 was the Molecule of the Week for October 5, 2015. It is an insecticide that the US Environmental Protection Agency approved for use in 2013. In 2015, EPA banned its use because of its toxicity to honeybees; but, controversially, in 2019, under the Trump administration, the agency reauthorized its use on several crops. This past December, the US Court of Appeals for the 9th Circuit ruled that the EPA broke the law by reauthorizing sulfoxaflor because it failed to assess endangered species risks and did not give the public a chance to comment on its decision.

1. CAS Reg. No. 946578-00-3.

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