Carfilzomib, a selective proteasome inhibitor, is marketed by Onyx Pharmaceuticals under the name Kyprolis. FDA approved the epoxomicin derivative in July 2012 for treating patients with relapsed, refractory multiple myeloma. Work by C. M. Crews and co-workers at Yale University led directly to the development of carfilzomib.
Carfilzomib is a selective proteasome inhibitor that is used to treat patients with relapsed, refractory multiple myeloma. But recently, data analysis of 24 clinical trials on carfilzomib revealed a high incidence of adverse cardiac events, many of which were severe or life-threatening.
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