Isosorbide is a sugar dehydration product. It was first prepared by W. N. Haworth and L. F. Wiggins in 1948 by dehydrating D-sorbitol, which is obtained by reducing D-glucose. Originally used as a diuretic and an isosorbide dinitrate precursor, it is now sold as a biobased chemical by Archer Daniels Midland. Isosorbide is a potential replacement for bisphenol A in plastics manufacture.
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