November 22, 2010
Image of Isosorbide 3D Image of Isosorbide

Isosorbide is a sugar dehydration product. It was first prepared by W. N. Haworth and L. F. Wiggins in 1948 by dehydrating D-sorbitol, which is obtained by reducing D-glucose. Originally used as a diuretic and an isosorbide dinitrate precursor, it is now sold as a biobased chemical by Archer Daniels Midland. Isosorbide is a potential replacement for bisphenol A in plastics manufacture.

MOTW update: September 30, 2019

Isosorbide was the Molecule of the Week for November 22, 2010. It is a sugar dehydration product that has been examined as a safe replacement for bisphenol A in plastics manufacture. At the recent ACS National Meeting in San Diego, Florence Popowycz of the University of Lyon (France) gave a paper based on her 2018 article “Diastereoselective iridium-catalyzed amination of biosourced isohexides through borrowing hydrogen methodology” Popowycz’s process uses corn-derived isosorbide as one of the substrates.

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